CRISMA The Clinical Research, Investigation, and Systems Modeling of Acute Illness (CRISMA) Center is directed by Derek C. Angus MD, MPH, and is comprised of six programs: Systems biology directed by Gilles Clermont MD, MSc; Healthcare Policy and Management to be directed by Jeremy Kahn, MD, MS; Bioengineering and Organ Support directed by John Kellum, MD; CRISMA-Kids directed by R Scott Watson, MD, MPH; Ethics and Decision-Making directed by Douglas White, MD, MAS; and Clinical Epidemiology directed by Dr. Angus. CRISMA includes adult and pediatric critical care researchers and dedicated research staff that specialize in translational research of the acutely ill. This large team of clinician-scientists, mathematicians, and epidemiologists enjoys superb funding from the NIH and multiple industrial sponsors. Regarded by many as one of world’s foremost translational research groups with 16 core faculty members and over 14 million dollars in federal research funding, CRISMA is actively studying sepsis, a syndrome that affects about 750,000 Americans every year and carries a mortality rate of almost 30 percent, and sepsis-induced organ dysfunction. This team of scientists has published papers in leading journals such as the New England Journal of Medicine, JAMA, Lancet, Critical Care Medicine, the Journal of the American Society of Nephrology, Kidney international, and the American Journal of Respiratory and Critical Care Medicine. CRISMA also collaborates with industry, advises in clinical trial design and implementation, and mentors clinical and research fellows, most of whom are simultaneously completing advanced training in clinical and health services research through the Masters in Public Health (MPH) program at the Graduate School of Public Health, the Clinical Research Training Program, or the Clinician Educator Training Program.