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International Forum
for Acute Care Trialists

Global collaboration of acute care clinicians and researchers


Research programs to improve the care of critically ill patients

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Working Groups Working Groups

Facilitate collaboration & cooperation
between Clinical Trials Networks

InFACT seeks to improve the care
of acutely ill patients around the world.


Causes, prevention, and management of acute, life-threatening illness.

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Join our international
network of trial groups

InFACT is a network of autonomous
clinical research groups


We encourage you to contact us for more information.

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Executive Members

  • ANZICS
  • ARDSNet
  • BRICNet
  • CCCCTG
  • CCCTG
  • CRISMA
  • ESICM
  • George Institute
  • GiViTI
  • GSA
  • ICNARC
  • ICS UK
  • ICCTG
  • LASI
  • SCCTG-Scottish
  • SCCTG-Scandinavian
  • SEPNET
  • SOAP Investigators
  • USCIITG

Latest News

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CALORIES trial

In a randomized controlled trial, investigators showed no difference in 30-day mortality between patients gettings early enteral nutrition, compared with early parenteral nutrition (NEJM, 2014)

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Declining mortality from sepsis

In a retrospective series from 171 ICUs in Australia and New Zealand, ANZICS investigators have shown a decline in absolute hospital mortality from 35.0% to 18.4% between 2000 and 2012. (JAMA, 2014)

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ProCESS - Protocolized Care for Early Septic Shock

In a 31 center randomized trial of three groups for the first 6 hours of resuscitation for septic shock in the emergency department, the ProCESS investigators demonstrated that a protocol-based resuscitation algorithm did not improve outcomes. (NEJM, 2014)

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